Correlation between immune factor and male infertility

    YANG Jiaª²Zhou1, ZHAO Yuª²Feng1, JING Caiª²Xia2, AI Qingª²Yan1, MIAO Naiª²Zhou1

    1Department of Histology & Embryology£¬ 2Department of Parasitology£¬ Medical College of Yan¬ðan University, Yan¬ðan 716000, China

    ¡¾Abstract¡¿ AIM: To examine the relationship between antisperm antibody (AsAb), anticardiolipin antibody (ACA) and antiª²toxoplasma antibody in the sera of inferlile of males, and other indexes of semen and to study the correlation and mechanism of AsAb, ACA, antiª²toxoplasma antibody and infertility. METHODS: AsAb, ACA and antiª²toxoplasma antibody in sera from 286 cases of male infertile patients and 198 normal persons were measured with enzymeª²linked immunosorbent assay (ELISA) and other indexes of semen were also detected. RESULTS: The positive rate of AsAb (29.4%), ACA (18.2%) and antiª²toxoplasma antibody (17.1%) in the sera of infertile patients was significantly higher than that of normal controls (9.0%, 7.0% and 9.0%, respectively, P<0.01). The change of AsAb level could cause a remarkable decrease of sperm activity and a significant positive correlation was found (P<0.01). CONCLUSION: AsAb is closely related to male infertility and may lead to a remarkable decrease of sperm activity, but it does not significantly affect sperm density and liquidization. ......