人鼠间同种和异种混合淋巴细胞反应的对比
混合淋巴细胞反应,,混合淋巴细胞反应;,CD4;,CD8,0引言,1材料和方法,2结果,3讨论,【参考文献】
Comparative study on xeno and alloMLRs between human and miceWANG YingYu, WANG YunJie, ZHANG Rui
Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an 710038, China
【Abstract】 AIM: To compare MLRs with xenoAgs and alloAgs in vitro. METHODS: Xeno and alloMLRs were set up and a cellular classification study of xeno and alloMLRs was performed. RESULTS: The response of human lymphocytes to xenogenic cells was weaker than that to allogenic cells. The cellular classification study indicated that the human antimice xenoresponse to murine Ags was through an indirect pathway, while the majority of human antihuman alloresponse to human Ags was through a direct pathway. In all the responses, human CD4+ T cells were the major response cells, though CD8+ T cells were also involved as well. CONCLUSION: The response of human T cells to xenogenic cells is weaker than that to allogenic cells. Antigen presenting cell (APC) is involved in both alloMLRs and xenoMLRs. There are direct and indirect pathways in alloMLRs, but only indirect pathways in xenoMLRs. ......
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