骨肉瘤_____骨肉瘤；单核细胞；侵袭(期刊论文)

人骨肉瘤细胞系MG63体外增强单核细胞的迁移及侵袭能力

http://www.100md.com 《第四军医大学学报》 2004年第14期

骨肉瘤,,骨肉瘤；单核细胞；侵袭,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Migration and invasiveness of monocytes enhanced by human osteosarcoma cell line MG63 in vitro

    WU YinSong, WANG Zhen

    PLA Institute of Orthopaedics, Xijing Hospital, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To investigate the migration and invasiveness of monocytes cocultured with osteosarcoma cells. METHODS: An in vitro monocytetumor cculture model was established, and the migration and invasiveness ability of human monocyte line Thp1 after coculture was measured by Transwell test and the MMP9 expression of monocytes was detected by gelatin zymography. RESULTS: Migration and invasiveness of Thp1 cells after coculture were enhanced after coculture with osteosarcoma cells (P<0.01) and gelatin zymography showed that the expression of MMP9 in Thp1 supernatant also increased. CONCLUSION: Osteosarcoma cells can alter the migration and invasiveness of monocytes, probably by the induction of MMP9 expression.

    【Keywords】 osteosarcoma; monocytes; invasiveness

    【摘要】目的：观察骨肉瘤细胞对单核细胞侵袭能力的影响 ......

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