动脉粥样硬化_____动脉粥样硬化；雄激素受体基因；甲基化

动脉粥样硬化AR基因甲基化修饰的初步探讨

http://www.100md.com 《第四军医大学学报》 2004年第15期

动脉粥样硬化,,动脉粥样硬化；雄激素受体基因；甲基化,0引言,1对象和方法,2结果,3讨论,【参考文献】

     Study on methylation of AR gene in atherosclerosis

    WEI YaNing, SHU Qing, ZHANG SuZhen

    Department of Medical Genetics and Developmental Biology, School of Basic Medicine, Fourth Military Medical University, Xi’an 710033, China

    【Abstract】 AIM: To discuss the relationship between methylation of androgen receptor (AR) gene CpG island and atherosclerosis. METHODS: Hypersensitive methylation of restriction endonuclease and polymerase chain reaction were used to detect the methylation of AR gene CpG island in 96 atherosclerosis patients and ninetyone control cases. RESULTS: The methylation in male patients was lower than that in male control (P<0.05). The methylation had no obvious change between female patients and female control (P>0.05). Male patients had lower methylation than that of female patients (P<0.05) but there was no significant difference of methylation between male and female (P>0.05). CONCLUSION: The dismethylation of AR gene CpG island may partly induce atherosclerosis.

    【Keywords】 atherosclerosis; androgen receptor gene; methylation

    【摘要】目的：探讨雄激素受体(AR)基因CpG岛(CCGG)胞嘧啶甲基化模式与动脉粥样硬化(Atherosclerosis, AS)的关系. 方法：应用甲基化敏感的限制性内切酶及聚合酶链式反应(PCR)对96例动脉粥样硬化患者、91例正常对照人群AR基因CpG岛甲基化模式进行比较 ......

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