Changes of electroretinogram in earlyª²stage diabetic rats

    DAI Haiª²Bin, CHANG Yaoª²Ming, ZHANG Zuoª²Ming, DING Zhenª²Qiang, LI Jingª²Sheng

    1Department of Aerospace Hygiene & Health Service, 2Department of Aerospace Clinical Medicine, School of Aerospace & Aviation Medicine, Fourth Military Medical University, Xi¬ðan 710033, China

    ¡¾Abstract¡¿ AIM: To observe the changes of electroretinogram of Spragueª²Dawley rats with earlyª²stage (within 5 weeks) diabetes. METHODS: According to standard program recommended by International Society for Clinical Visual Electrophysiology, we recorded the rodª²response, maxª²response, oscillatory potentials (OPs), photopic electroretinograph (photª²ERG) and 20 Hz flicker response in earlyª²stage diabetic rats induced by streptozotocin (STZ) and ageª²matched control ones. RESULTS: Before and at the first week after onset of diabetes, the ERG of diabetic rats did not differ significantly from that of control ones but at the second and fifth week, the implicit times of b wave of rodª²response, b wave of maxª²response, O2 wave of OPs and b wave of photª²ERG of diabetic rats were respectively prolonged significantly compared to those of control ones. However, no significant difference was found between the ERG amplitudes of diabetic rats and those of control ones. CONCLUSION: The observations indicate that the implicit times of b wave of rodª²response, b wave of maxª²response, O2 wave of OPs and b wave of photª²ERG are respectively prolonged significantly in earlyª²stage diabetic rats, which can be used as indicators inspecting the early development of diabetic retinopathy. ......