芪丹通脉片__(期刊论文)

芪丹通脉片预防大鼠急性心肌缺血及对VEGF， bFGF表达的影响

http://www.100md.com 《第四军医大学学报》 2003年第7期

芪丹通脉片,,芪丹通脉片；血管内皮生长因子；碱性成纤维细胞生长因子,芪丹通脉片预防大鼠急性心肌缺血及对VEGF，bFGF表达的影响,0引言,1材料和方法,2结果,3讨论,【参考文献】

     (第四军医大学：西京医院中医科，预防医学系流行病学教研室，陕西西安710033)

    Preventive effects of Qidantongmai Tablet on acute myocardial infarction in mice and its influence on expression of VEGF and bFGF

    WANG ZongRen, LI JingHua, XIAO TieHui, SHAO ZhongJun, MA Jing, ZHENG Jin, MA AiLing, LONG Yin, WANG Wen, LI JunChang

    Department of Traditional Chinese Medicine, Xijing Hospital, Department of Epidemiology, Facalty of Preventive Medicine, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To investigate the preventive effects of QiDanTongMai Tablet (QDTMT) on mouse acute infarction and its possible mechanism. METHODS: SD mice were divided into control group, infarction group, QDTMT max dose group and QDTMT min dose group randomly. Different concentrations of QDTMT were administered to the four groups at same dosage twice a day for fourteen days before ligation. Coronary artery was ligated to establish the infarction animal model. Immunohistochemistry methods were used to detect the expression of VEGF and bFGF. RESULTS: Compared with that of the infarction group, the concentration of CPK and LDH decreased in all the QDTMT groups [LDH: (946±83) U·L-1, (754±75) U·L-1 vs (1582±90) U·L-1, (P<0.01); CPK: (1135±69) U·L-1, (960±39) U·L-1 vs (1513±47) U·L-1, (P<0.01)]. Infarction size in all the QDTMT groups decreased, and the left ventricular functions improved. QDTMT enhanced the expression of VEGF and bFGF. CONCLUSION: QiDanTongMai Tablet can prevent acute myocardial ischemia and enhance the expression of VEGF and bFGF. ......

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