Correlation of expression of TGFª²beta and angiogenesis in nonª²small cell lung cancer

    WEI Xiaoª²Hong, DU Fengª²Lan, WANG Hongª²Yan

    1Department of Respiratory Medicine, 2Department of Pathology, First Hospital, Xi¡¯an Jiaotong University, Xi¡¯an 710061, China

    ¡¾Abstract¡¿ AIM: To investigate the correlation between the expression of transforming growth factor beta (TGF¦Â) and the angiogenesis in nonª²small cell lung cancer (NSCLC). METHODS: MVC and expression of TGF¦Â1 in 50 carcinomatous specimens and expression of TGF¦Â1 in 35 paraª²carcinomatous specimens from the same 50 cases with NSCLC were detected by SP immunohistochemistry. RESULTS: Active angiogenesis in NSCLC was detected and it was related with NSCLC progression and lymph node metastasis, but not related with histological types. Significant difference of the expression of TGF¦Â1 was found between stage ¢ñ and ¢ò (P<0.05), and between stage ¢ñ and ¢ó (P<0.05), and the positive expression of TGF¦Â1 was significantly higher in the patients with lymph node metastasis than those without lymph node metastasis (P<0.01). No significant association was found between the TGF¦Â1 expression and the characteristics of the histological types in NSCLC. Positive TGF¦Â1 expression in carcinomatous specimen was stronger than that in paraª²carcinomatous specimen. TGF¦Â1 expression was correlated with tumor angiogenesis. CONCLUSION: TGF¦Â highly promotes the progression and lymph node metastasis of NSCLC, mainly by stimulating angiogenesis. ......