muc1基因在乳腺癌中的表达及其临床意义
乳腺肿瘤,,乳腺肿瘤;MUC1;免疫组织化学,0引言,1材料和方法,2结果,3讨论,【参考文献】
Expression of muc1 in breast cancer tissues and its clinical significanceWANG Ling, YUAN ShiFang, YAO Qing, LING Rui, LI KaiZong
1Department of Vascular and Endocrine Surgery, 2Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710033, China
【Abstract】 AIM: To investigate the expression of muc1 in breast cancer tissues, and to explore its clinical significance. METHODS: The expression level of MUC1 was detected by a detailed immunohistochemical analysis in 86 samples of breast carcinoma and in 40 samples of benign tumor tissues. RESULTS: The positivity rate of MUC1 in breast cancer was 56%, much higher than that in breast benign tumors, which was 8% (P﹤0.01). There was no relationship between the expression of MUC1 and the pathological types (P>0.05). In breast cancers with lymph node metastasis, the positivity rate of MUC1 was 65% and in breast cancers without metastasis, it was 44%. There was a significant difference between the two groups (P<0.05). CONCLUSION: The results suggest that the high expression of MUC1 in breast cancer may be significant for the diagnosis of breast carcinoma. The high expression levels of MUC1 may be a prognostic factor for the treatment of breast cancer. ......
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