神经干细胞_____神经干细胞；缺血；移植

类缺血皮质神经元对小鼠外源性神经干细胞增殖作用的影响

http://www.100md.com 《第四军医大学学报》 2003年第7期

神经干细胞,,神经干细胞；缺血；移植,0引言,1材料和方法,2结果,3讨论,【参考文献】

     (第四军医大学西京医院神经内科，陕西西安 710033)

    Effects of cortical neurons pretreated by ischemiclike conditions on proliferation of extrinsic mouse neural stem cells

    LI Li , WAN Qi, LIU YongHong, ZHANG RuiGuo

    Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To investigate the effects of cortical neurons pretreated in ischemiclike condition on extrinsic neural stem cells' proliferation. METHODS: The cortical neurons pretreated under ischemiclike condition were cocultured with neural stem cells and the number of survived neural stem cells was detected by MTT assay. RESULTS: Compared with the two control groups, the neural stem cells cocultured with ischemicconditiontreated neurons had an accelerated proliferative speed and a higher vitality in 23 weeks. CONCLUSION: Cortical neuronal cells injured in ischemiclike conditions can significantly promote the cocultured neural stem cells proliferation.

    【Keywords】 neural stem cells; ischemia; transplantation

    【摘要】目的：研究类缺血损伤的皮质神经元对外源性神经干细胞增殖的影响作用. 方法：类缺血处理后的小鼠皮质神经细胞与同种异体神经干细胞共培养 ......

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