1993, 233 (4) : 7052715.

    [ 2 ] Rajamohan F, Pugm ireM J , Kurinov IV , et al . Modeling

    and alanine scanning mutagenesis studies of recombinant

    pokeweed ant iviral p ro tein [J ]1 J B iol Chem , 2000, 275 (5) :

    338223390.

    [ 3 ] Hur Y, Hwang D J , Zoubenko O , et al . Iso lat ion and charac2

    terizat ion of pokeweed ant iviral p ro tein mutat ions in S accha2

    romy ces cerev isiae: ident if icat ion of residues impo rtant fo r

    toxicity [J ]1 P rocN atl A cad S ciUSA , 1995, 92 (18) : 84482

    8452.

    [4 ] Hudak K A , D inman J D, Tumer N E. Pokeweed ant iviral

    p ro tein accesses ribo somes by binding to L 3 [ J ] 1 J B iol

    Chem , 1999, 274 (6) : 385923864.

    [ 5 ] Rajamohan F, M ao C, U ckun F M. Binding interact ions be2

    tween the act ive center clef t of recombinant pokeweed ant ivi2

    ral p ro tein and the alpha2sarcin? ricin stem loop of ribo somal

    RNA [J ]1 J B iol Chem , 2001, 276 (26) : 24075224081.

    [ 6 ] Rajamohan F, Ozer Z, M ao C, et al . A ct ive center clef t

    residues of pokeweed ant iviral p ro tein mediate its h igh2 aff ini2

    ty binding to the ribo somal p ro tein L 3 [ J ] 1 B iochem istry ,2001, 40 (3) : 910429114.

    [ 7 ] Monzingo A F, Robertus J D. X2ray analysis of subst rate

    analogs in the ricin A 2 chain act ive site [ J ] 1 J M ol B iol,1992, 222: 113621145.

    [ 8 ] Ren J , W ang Y, Dong Y. The N 2 glyco sidase mechanism of

    ribo some2inact ivat ing p ro teins imp lied by crystal st ructures

    of alpha2 momo rcharin [J ]1 S tructu re, 1994, 2: 7216.

    [ 9 ] Huang Q C, L iu S P, Tang Y Q. Studies on crystal st ruc2

    tures, act ive2center geomet ry and depurinat ing mechanism of

    two ribo some2inact ivat ing p ro teins [ J ] 1 B iochem J , 1995,309: 2852298.

    [ 10 ] Poyet J L , Hoeveler A , Jongeneel C V. A nalysis of act ive

    site residues of the ant iviral p ro tein f rom summer leaves

    f rom P hy tolacca am ericana by site2 directed mutagenesis [J ]1

    B iochem B iop hy s R es Comm un, 1998, 253 (3) : 5822587.

    [ 11 ] Zarling JM , Mo ran P A , HaffarO , et al . Inh ibit ion of H IV

    rep licat ion by pokeweed ant iviral p ro tein targeted to CD4+

    cells by monoclonal ant ibodies [ J ] 1 N atu re, 1990, 347

    (6288) : 92295.

    [ 12 ] Rajamohan F, V enkatachalam T K, Irvin J D, et al . Poke2

    weed ant iviral p ro tein isofo rm s PA P21, PA P2II , and PA P2

    III depurinate RNA of human immunodef iciency virus

    (H IV ) 21 [ J ] 1 B iochem B iop hy s R es Comm un, 1999, 260

    (2) : 4532458.

    [ 13 ] Rajamohan F, Kurinov I V , V enkatachalam T K, et al .

    Deguanylat ion of human immuno2 def iciency virus (H IV 21)

    RNA by recombinant pokeweed ant iviral p ro tein [ J ] 1

    B iochem B iop hy s R es Comm un, 1999, 263 (2) : 4192424.

    [ 14 ] Tumer N E, Hwang D J , BonnessM. C2term inal delet ion

    mutant of pokeweed ant iviral p ro tein inh ibits viral infect ion

    but does no t depurinate ho st ribo somes [J ]1 P roc N atl A cad

    S ci USA , 1997, 94 (8) : 386623871.

    [ 15 ] Hudak K A , W ang P, Tumer N E. A novel mechanism fo r

    inh ibit ion of t ranslat ion by pokeweed ant iviral p ro tein:

    depurinat ion of the capped RNA temp late [J ]1 RN A , 2000,6 (3) : 3692380.

    [ 16 ] Erice A , Balfour H H J r, M yersD E, et al . A nt i2 human im2

    munodef iciency virus type 1. act ivity of an ant i2 CD4 immuno2

    conjugate containing pokeweed ant iviral p ro tein [J ]1 A ntim i2 ......