关键词: 肺/损伤;扎鲁司特;受体，白三烯/拮抗剂和抑制剂

    摘 要:目的 观察扎鲁司特(zafirlukast)对急性肺损伤的防治作用. 方法 新西兰大白兔24只，随机分为对照组(n=8)，致伤组(n=8)，扎鲁司特治疗组(n=8).致伤组经颈静脉注入内毒素(LPS，1mL kg-1 )，对照组经颈静脉注入生理盐水(1ml kg-1 )，治疗组经颈静脉注入内毒素(LPS，1mL kg-1 )前1h及30min，胃内注入扎鲁司特(20mg kg-1 ).测定各组肺动脉压、氧分压、外周血白细胞计数、肺泡灌洗液NO浓度、肺系数(肺湿质量/体质量)及肺湿/干比，并取肺活组织行HE染色. 结果 治疗组肺动脉压及NO浓度与致伤组无显著差别(P>0.05)，氧分压较致伤组明显改善(P<0.01)，肺系数和肺湿/干比显著低于致伤组(P<0.01)，外周血白细胞高于致伤组(P<0.01).病理检查结果显示，治疗组肺损伤减轻. 结论 扎鲁司特对急性肺损伤有一定的防治作用.

    Preventive effect of zafirlukast against acute lung injury

    MU De-Guang，LI Huan-Zhang

    Department of Respiratory Medicine，Xijing Hospi-tal，Fourth Military Medical University，Xi'an710033，China

    Keywords:lung/injuries;zafirlukast;receptors，leuko-triene/antagonists&inhibitors

    Abstract:AIM To observe the preventive effect of zafir-lukast against acute lung injury.METHODS 24New-Zealand rabbits were randomly divided into three groups:Control group(n=8)，injury group(n=8)，and treatment group(n=8).into rats in injury group was Endotoxin(LPS，1mL kg-1 )，normal saline(1mL kg-1 )in control group ......