关键词: 受体，雌激素;受体，孕酮;静脉曲张

    摘 要:目的 研究在正常及曲张的大隐静脉壁上雌激素(E)和黄体酮(P)受体的表达. 方法 采用29名健康人群的大隐静脉及32名静脉曲张患者的曲张和正常静脉标本，经固定处理后运用抗雌激素和抗黄体酮受体的抗体染色，再进行核染色密度和范围积分计数. 结果 在男性和女性的血管中膜、内膜核区均检测到了两种激素的受体.在血管外膜，仅在曲张血管的核区检测到两种激素的受体.在曲张血管的非扩张部，其雌激素的表达低于正常人的正常血管.在同一曲张血管中，尤其是女性，扩张区雌激素表达水平远远高于非扩张区.而黄体酮受体水平在曲张静脉非扩张区部分女性高于男性. 结论 性激素是静脉曲张形成的一种重要因素.

    Estrogen and progesterone recepters in normal and varicose saphenous veins

    LI Nan-Lin WANG Ling DUAN Xiao-Li MA Fu-Cheng WANG Ying-Mei

    1 Department of Vascular Surgery，Xijing Hospital，

    2 Institute of Neuroscience of Chinese PLA，

    3 Department of Pathology，Xijing Hospital，Fourth Military Medical University，Xi'an710033，China keywords:receptors，estrogen;receptors，progesterone;varicose veins

    Abstract:AIM To investigate the presence of estrogen and progesterone receptors in the walls of normal and varicose vein.METHODS Fixed sections，from the saphenous veins of29normal individuals and from varicose and normal vein segments of32patients with varicose vein，were stained with anti-estrogen or anti-progesterone receptor antobodies.Nu-clear stain density and scope were scored.RESULTS Recep-tors to both hormones were detected in the nuclear regions of the intima and media in females and males.In the adventitia ......