关键词: 应激，心理学;胃动力;粘膜损伤

    摘 要:目的 观察心理性应激对大鼠胃排空的影响及胃粘膜的损伤. 方法 建立心理性应激大鼠模型.利用放射免疫分析及组织化学的方法观察，心理性应激条件下大鼠胃排空和胃粘膜损伤的情况以及二者之间的关系. 结果 心理性应激可以导致胃排空障碍，在应激的第3日大鼠的胃排空明显降低(82.1±4.5)%，在应激第5日和第7日大鼠的胃排空降低更加明显(78.4±5.4)%，(78.2±6.5)%;而胃粘膜的损伤，随着应激时间的增加，胃粘膜损伤不断增强.在应激第3日大鼠的胃粘膜损伤指数为(28.6±3.6)，在应激第5日和第7日大鼠的胃粘膜损伤指数逐渐增加(32.1±4.2，34.6±4.8). 结论 心理性应激可导致胃排空障碍和胃粘膜损伤，而且二者与应激源作用的时间密切相关.

    Effect of psychological stress on gastric emptying and gastric mucosal lesions in rats

    HAO Yue，HUANG Yu-Xin，WANG Jing-Jie

    Department of Gastroenterology，Tangdu Hospital，Fourth Military Medical University，Xi'an710038，China

    Keywords:stress，psychology;gastric motor;mucosal lesion

    Abstract:AIM To observe the gastric motor disorders and gastric mucosal lesions under psychological stress in rats.METHODS The model of psychological stress rat was es-tablished.Using radioimmunoassay and histochemical stain-ing were used to observe the gastric motor disorders and gas-tric mucosal lesions under psychological stress in rats and ralationship of them.RESULTS Psychological stress caused the gastric emptying disorders.On the3rd day under psycho-logical stress ......