Effects of Qidantongmai tablet on LDH and oxygen free radical of cerebral ischemia reperfusion injury in rats

    WANG Xing, WANG Zongª²Ren, WANG Sanª²Hu, LI Feng, ZHAO Yanª²Ling£¬ MA Jing, LI Jun

    Chang, WANG Wen, LIU Anª²Heng

    1Department of Traditional Chinese Medicine, 3Department of Cardiovasology, Xijing Hospital, Fourth Military Medical University, Xi¡¯an 710033, China, 2Traditional Chinese Medicine Hospital of Xi¡¯an, Xi¡¯an 710077, China

    ¡¾Abstract¡¿ AIM: To observe the Qidantongmai tablet(QDTMT)effects against rat cerebral ischemia reperfusion injury and to explore its mechanism. METHODS: Seventy SD rats were divided randomly into control group, model group, QDTMT low dose group, QDTMT medium dose group, QDTMT high dose group, HuaTuo Reconstruction Pill (HTRP) group, nimodipine (NIMO) group (n=10). Different drug or normal saline was administered to the 7 groups at the same dosage once a day for seven days before operation. Then cerebral ischemia reperfusion models were established and the activity of lactate dehydrogenase (LDH), superoxide dismutase (SOD) and the content of malondial dehyde (MDA) were studied. RESULTS: Compared with those of control group, the activity of LDH and content of MDA in the model group were higher while the activity of SOD was lower, and the differences were significantly (P<0.01). Compared with those of the model group, the activity of LDH decreased significantly, the content of MDA decreased significantly, and the activity of SOD also decreased significantly (P<0.01) in different dose groups of QDTMT as well as the HTRP group and the NIMO group. CONCLUSION: QDTMT has some marked effects against cerebral ischemia reperfusion injury in rats, perhaps owing to anti oxygen free radicals. ......