关键词: 导管消融术;VX2肿瘤;兔;肺肿瘤;脱噬作用

    摘 要:目的 探讨射频消融兔肺内VX2肿瘤诱导肿瘤细胞凋亡情况. 方法 采用VX2肿瘤组织块悬液肺内注入法在20只新西兰白兔体内建立兔VX2肿瘤肺内移植模型;实验组12只新西兰白兔给予射频治疗，计数毁损中心区肿瘤组织和边缘区肿瘤组织凋亡细胞指数;对照组8只新西兰白兔，予假性治疗，计数肿瘤组织凋亡细胞指数. 结果 治疗组肿瘤经射频治疗后发生凝固性坏死及细胞凋亡，毁损边缘区肿瘤组织凋亡细胞指数为(345±38)，而毁损中心区肿瘤组织凋亡细胞指数为(84±12)，两者差异非常显著(P<0.01);对照组肿瘤组织凋亡细胞指数为(2.0±0.4)，与治疗组毁损区中心组织凋亡细胞指数及毁损区边缘组织凋亡细胞指数相比均相差非常显著(P<0.01). 结论 射频消融诱导肿瘤细胞凋亡是射频治疗恶性肿瘤的一项重要机制.

    Apoptosis induced by radiofrequency ablation on the VX2tumor in rabbit lung

    MA Lian-Jun，CHENG Qing-Shu，ZHANG Wei-Qiang，LIU Kun，WANG Yun-Jie，WANG Dao-Xi，ZHAO Zheng-Yuan，QI Hai-Ni，DU Ming-Xiang

    Department of Thoracic Surgery，Tangdu Hospital，Fourth Military Medical University，Xi'an710038，China

    Keywords:catheter ablation;VX2tumor;rabbits;lung neo-plasms;apoptosis

    Abstract:AIM To observe status of cell apoptosis of VX2tumor in rabbit lung after radiofrequency ablation.METH┐ODS By injecting VX2tumor tissue suspension in the lung，the transplanted lung cancer model was established in20New Zealand white rabbits.12rabbits were treated with radiofre-quency ablatoin ......