五灵胶囊对LPS诱导枯否细胞释放细胞因子的影响
五灵胶囊,,五灵胶囊;,枯否细胞;,细胞因子;脂多糖,0引言,1材料和方法,2结果,3讨论,【参考文献】
Effects of WuLing Capsules on lipopolysaccharideinduced kupffer’s cells’ secretion of cytokineWANG ShengChun, ZHANG YingZhi, HU YongWu, LI XiaoWei, TIAN WeiBin
Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi’an 710033, China
【Abstract】 AIM: To investigate the effects of WuLing Capsules on liver cell injuries induced by active molecules secreted by Kupffer’s cells. METHODS: Hepatocyte and Kupffer’s cells were isolated and purified from rat livers and then exposed to LPS and DGlan. The changes of hepatocytes and cytokines secreted from Kupffer’s cells were determined in the presence of WuLing Capsules. The protective effects of WuLing Capsule on hepatocyte injuries induced by LPS stimulation of kupffer’s cells were also examined. RESULTS: WuLing Capsules significantly reduced hepatocyte injuries induced by LPS and DGlan exposure and inhibited TNFα, IL6 and IL8 secretion of Kupffer’s cells. The hepatocyte injuries caused by active molecules released from Kupffer’s cells decreased in the presence of WuLing Capsule. CONCLUSION: WuLing Capsule may exert some therapeutic effects by the down regulation of cytokines in chronic hepatitis. ......
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