关键词: 前列腺肿瘤;CD44;基因;免疫组织化学

    摘 要:目的 探讨转移相关基因CD44v6在前列腺癌中的表达及意义. 方法 以免疫组化S-P法对67例前列腺癌标本进行染色及分析. 结果 CD44v6在前列腺癌中有较高的表达，阳性率为41.8%(28/67).其中无转移者阳性率为16.0%(4/25)，有淋巴结或远处转移者阳性率57.1%(24/42)，两者比较差异有显著性(P<0.01)CD44v6阳性表达与前列腺癌分化程度(r=0.463，P<0.05)及临床分期(r=0.412，P<0.05)相关显著.CD44v6阳性的前列腺癌患者术后生存期显著低于阴性患者(9.5%vs39.3%，P<0.05). 结论 CD44v6阳性表达与前列腺癌的发生、发展及预后有关.

    Expression of metastasis┐associated gene CD44v6in prostate cancer tissue

    CUI Fei-Lun Chen Bing WANG Yuan-Zheng WANG Zhong-Kun CHEN Rong-Shan

    1 Department of Urology，Chinese PLA205Hospi-tal，

    2 Department of Urology，First Affiliated Hos-pital，Jinzhou Medical College，Jinzhou121000，China，

    3 Department of Urology，Xijing Hospital，Fourth Military Medical University，Xi'an710033，China

    Keywords:prostatic neoplasms;CD44;genes;immunohis-tochemistry

    Abstract:AIM To evaluate the expression of metastasis as-sociated gene CD44v6in prostate cancer tissue and its signifi┐cance.METHODS The expression of CD44v6in67human prostate cancer specimens was studied by immunohis-tochemical S-P technique.RESULTS The positive rate of CD44v6was41.8%(28/67).The positive staining was high-er in metastasis patients(57.1%)than in patients without metastasis(16.0%)of prostate cancer(P<0.01).The ex-pression of CD44v6was correlated with cell grade(r=0.463 ......