免疫印迹法检测IKK, IκB和NFκB在喉癌中的表达
喉肿瘤,,喉肿瘤;免疫印迹法;IKB激酶;IκB;核因子κB,免疫印迹法检测IKK,IκB和NFκB在喉癌中的表达,0引言,1材料和方法,2结果,3讨论,【参考文献】
Expression of IKK, IκB and NFκB in laryngeal carcinomas: A Western blot studyZHU Jiang, HU GuoHua, SUN YuCai
1Department of Otolaryngology, First Hospital, Chongqing University of Medical Sciences, Chongqing 400016, China, 2Department of Otolaryngology, Affiliated Hospital, Jinin Medical College, Jinin 272129, China
【Abstract】 AIM: To detect the expression of IKK, IκB and NFκB in laryngeal carcinomas and to explore its significance for the genesis and development of carcinomas. METHODS: The expression of IKKα, IκBα and NFκB p65 in 20 cases of laryngeal carcinomas and 10 cases of normal laryngeal tissues was detected by Western blot technique. RESULTS: The expression of IKKα and NFκB p65 in laryngeal carcinoma tissues was higher compared with that in normal laryngeal tissues and the expression of IκBα was lower (P<0.05). CONCLUSION: The expression imbalance of IKK, IκB and NFκB is closely associated with the genesis and development of laryngeal carcinomas. ......
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