关键词: 肝炎，乙型;宫内传播;感染率;Meta分析

    摘 要:目的 分析不同孕期乙型肝炎病毒宫内感染率的差异，探索HBV宫内感染发生的时间. 方法 运用Meta分析技术对9个不同孕期HBV母胎传播发生率研究进行定量综合分析. 结果 孕早期的宫内感染率最低(0.48%)，而孕晚期的感染率(14.07%)高于孕中期(4.33%)(d=0.1049，95.00%CI=0.052-0.158).对各研究结果做齐性检验，未见显著差异(P>0.05). 结论 HBV宫内感染可发生在孕期的各个阶段，但主要的发生时间是孕晚期.

    Meta┐analysis of intrauterine infection rate of HBV in different periods of pregnancy

    YAN Yong-Ping LI Duan XU De-Zhong CHEN Chang-Sheng WANG Xue-Ping

    1 Department of Epidemiology，

    2 Department of Health Statistics，Faculty of Preventive Medicine，Fourth Military Medical University，Xi'an710033，China

    Keywords:hepatitis B;intrauterine transmission;infection rate;Meta-analysis

    Abstract:AIM To analyze the difference of intrauterine in-fection rate in different periods of pregnancy and to determine the timing of HBV intrauterine infection.METHODS Meta-analysis was used to evaluate the data extracted from9pub-lished papers which were about the infection rate among dif-ferent periods in HBV intrauterine infection.RESULTS In-trauterine infection rate at early gestation was the lowest(0.48%) ......