(江苏省徐州市心血管病研究所， 江苏 徐州 221009

    江苏省徐州市中心医院， 江苏 徐州 221009)

    摘 要：目的：探讨实验室诊断在急性冠脉综合症早期诊断中的意义。方法：采用化学发光法测定68例冠心病(CHD)患者及40例正常对照组超敏C反应蛋白(hs-HS-CRP)、心肌肌钙蛋白I(cTnI)、肌红蛋白(Mb)、肌酸激酶同工酶(CK-MB)的阳性率。结果：CHD组患者的hs-HS-CRP、cTnI、Mb 、CK-MB的阳性率均明显高于正常对照组(P<0.05)。CHD组又分为3组，急性心机梗死组(AMI)20例、不稳定型心绞痛组(UA)28例、稳定型心绞痛组(SA)20例。AMI组患者的hs-HS-CRP、cTnI、CK-MB和Mb阳性率均明显高于SA组(P<0.01)；UA组hs-CRP和cTnI阳性率均明显高于SA组(P<0.01)，但两组间CK-MB和Mb阳性率相比无显著差异(P>0.05)。结论：冠心病发生与hs- HS-CRP和cTnI的增高相关。

    关键词： 超敏C反应蛋白； 心肌肌钙蛋白I； 肌酸激酶同工酶； 肌红蛋白； 冠心病

    Measurement of hs-C-Reactive Protein，Cardiac Troponin I，Creatine Kinase Isoenzyme MB and Myoglobin in the Diagnosis of Acute Coronary Syndrome

    WANG Lin-guang, et al

    (The angiocardiopathy Institute of Xuzhou, Jiangsu Xuzhou 221009, China)

    Abstract： Objective： To investigate the early diagnosis of acute coronary syndrome. Methods： By using immuneturbidity test and enzyme for rapid quantification，hs-C-reactive protein(hs-HS-CRP),cardiac troponin I (cTnI),creatine kinase isoenzyme MB (CK-MB)and myoglobin(Mb) were measured in 68 patients with acute coronary syndrome(ACS group) and 40 healthy volunteers (control group). Results： The positive rate of hs-HS-CRP, cTnI, CK-MB and Mb in ACS group was significantly higher than those in control group (P<0.05).The patients with ACS were divided into 3 groups: 25cases of acute my cocardial infarction (AMI group), 23 cases of unstable angina pectoris (UA group)and 20 cases of stable angina pectoris(SA group).The positivre rate of hs-HS-CRP, cTnI, CK-MB and Mb in the AMI group were significantly higher than those in the SA group (P<0.05),but there was no siginificant difference in the positive rate of of CK-MB and Mb between UA group and SA group. Conclusion： There was a significant correlation between the evalation of hs-HS-CRP, cTnI and the risk of ACS events. ......