宫颈肿瘤__(期刊论文)

HPV16、HSV2感染在子宫颈病变中的病理学意义

http://www.100md.com 《新疆医科大学学报》 2006年第1期

宫颈肿瘤,,HPV16、HSV2；宫颈肿瘤；免疫组化,1材料与方法,2结果,3讨论,参考文献：

     (新疆哈密地区中心医院病理科； 2哈密红星医院病理科； 3哈密第二人民医院病理科, 新疆哈密839000)

    摘要: 目的: 探讨人乳头状瘤病毒(HPV16)、单纯疱疹Ⅱ型病毒(HSV2)与子宫颈病变性质的病因发病学关系。方法: 应用免疫组化LSAB法对24例子宫颈湿疣、24例子宫颈上皮内瘤(CIN)和53例子宫颈浸润性鳞癌(SCC)组织进行HPV16、HSV2检测。结果：在子宫颈湿疣、CIN、SCC中HPV16检出率分别为62.5%、25.0%、66.0%；HSV2检出率分别为83.3%、41.6%、56.6%；HPV16、HSV2同时检出阳性率分别为54.1%、16.6%及43.3%。HPV16检出率随CIN、SCC病理分级增高而增加，不同民族的HPV16检出率差异无统计学意义。结论： HPV16感染是子宫颈癌发病的重要因素，且HSV2在子宫颈鳞癌的发病中具有协同作用。

    关键词: HPV16、HSV2；宫颈肿瘤；免疫组化

    Study on pathological signification of Cervical diseases infected by HPV16 and HPV2 of Uygur and Hans women in Xinjiang

    YANG Wen, LU Suai, Li Yutang, et al

    (Department of Pathology, Hami Prefecture Hospital of Xinjiang, Hami 839000, China)

    Abstract: Objective: To study the relationship between HPV16, HSV2 infection and human cervical lesions. Methods: Detection of HPV16, HSV2 in women patients with cervical intraepithelial neoplasia (CIN) 24, condyloma 24, and invasive squamous cell carcinoma (SCC) 53 by immunochemistry were carried out respectively. Results: The detected frequencies of HPV16 were 25.0% (6/24), 62.5% (15/24) , and 66.0% (35/53) in CIN, condyloma, and SCC respectively; the HSV2 were 41.6% (10/24) , 83.3% (20/24) and 56.6% (30/53) in CIN, condyloma, and SCC respectively. The frequency of HPV16 was higher in CINⅢ and SCC than in others. However, no statistic difference of these virogenes infection between Uygur and Hans women was found. Conclusions: HPV16 may be a critical etiologic factor for cervical carcinogenesis in human beings; HSV2 as a human papillomavirus cofactor in the etiology of invasive cervical cancer; The frequency of HPV16, HSV2 in cervical neplastic lesions no statistic difference in Uygur and Hans women in Hami was found. ......

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