摘要：目的：探讨ACE基因多态与HLA-B27阳性的关系。方法：应用 PCR扩增方法检测68例HLA-B27阳性患者和50例正常对照者ACE基因的16内含子中的287bp片段缺失/插入多态性。结果：HLA-B27阳性患者ACE基因插入纯合型(I/I)频率明显高于正常对照X2=4.21，p<0.05。结论：ACE基因插入纯合型(I/I)与HLA-B27阳性患者即强直性脊椎炎患者的易感性有关。

    关键词： 血管紧张素转换酶基因； 基因多肽性； 强直性脊椎炎

    Analysis of Angiotensin Convertible Enzyme (ACE)gene to HLA-B27 Positive Patients

    XU Qian， XING Gui-zhi， et al

    (The Hospital of Tangshan, Hebei Tangshan 063000, China)

    Abstract： Objective: To study the relationship of ACE gene and HLA-B27 . Method:ACE gene was analyzed for inserting and losing polymorphism of the 287 fragment in intron 16 by polymerase chain reaction(PCR). Result: The analysis revealed that the frequency of homozygous insertion of ACE gene(I/I) in HLA-B27 positive group(68 cases) is obviously higher than that of normal group(50 cases). Conclusion: The result supports that the homozygous insertion type of ACE gene(I/I) could be involved in the HLA-B27 positive patients so as to as patients. ......