Press(化学工业出版社) ,1995 :256～266

    Spectrophotometric Determination of Clotrimazole Based on Charge

    Transfer Reaction between Clotrimazole and Chloranilic Acid

    Li Huakan3

    , Zhao Guizhi , Zhao Yanqing , Li Zuo

    ( Jinzhou Medical College , Jinzhou 121001)

    Abstract A spectrophotometric method for the determination of clotrimazole is described. The charge transfer

    reaction between clotrimazole and chloranilic acid takes place in acetone solution. The composition of the charge

    transfer complex is 1∶ 1. Beer′ s law is obeyed in the range of 0～300 mg/ L with correlation coefficient 0. 9997. The

    apparent molar absorptivity is 1. 22 ×103

    L· mol

    - 1

    · cm- 1

    at 525 nm. The proposed method has been applied to

    determination of clotrimazole in tablets with satisfactory results. ......