基因_____P糖蛋白；基因，MDR；乳腺肿瘤

P糖蛋白在乳腺癌原发性耐药过程中的表达

http://www.100md.com 《第四军医大学学报》 2005年第16期

基因,,P糖蛋白；基因，MDR；乳腺肿瘤,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Pglycoprotein expression in the development of primary multidrug resistance in breast carcinoma

    ZHAO Fei, JIANG Jun, FAN LinJun, YANG XinHuan, ZHANG Yi

    Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China

    【Abstract】 AIM: To study the expression and significance of Pglycoprotein (Pgp) in the development of multidrug resistance in breast cancer. METHODS: The expression of Pgp and MDR1 mRNA were detected by immunohistochemistry and reverse transcriptionpolymerase chain reaction (RTPCR) in the specimens from 25 breast cancer patients with neoadjuvant chemotherapy (NAC group), 15 breast cancer patients without neoadjuvant chemotherapy (nonNAC group) and 10 patients with breast adenosis (control group). RESULTS: The positive rate of Pgp expression was 84.0%(21/25), 46.7%(7/15)and 0 in NAC group, nonNAC group and control group, respectively. MDR1 mRNA expression was 84.0%(21/25), 53.3%(8/15)and 10%(1/10) in three groups respectively. Significant difference was found between the three groups (P<0.01). CONCLUSION: Some tumor cells tolerances to chemotherapeutics increase during the process of oncogenesis and the tolerances can be induced by an extremely low expression of MDR1/Pgp. MDR1/Pgp is associated with the intrinsic multidrug resistance in breast carcinoma. ......

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