Captopril combined with irbesartan in treating patients with congestive heart failure

    ZHOU Quan£¬HU Zhenª²Yu£¬WU Daª²Fang£¬ZHANG Tongª²Li£¬ZHONG Xiaoª²Lan

    Department of Cardiovasology, PLA 451 Hospital, Xi¬ðan 710054£¬China

    ¡¾Abstract¡¿ AIM: To evaluate the effects of captopril combined with irbesartan in treating patients with congestive heart failure (CHF). METHODS: One hundred and twenty patients, who had unsatisfactory results by conventional treatment of digitalis, diuretics and ¦Âª²blocking agent, were randomly divided into group A and group B. Group A (n=60) was given captopril 50-150 mg/d and irbesartan 75-300 mg/d and Group B (n=60) was given captopril 50-150 mg/d. The changes of NYHA class, biochemistry, liver function, renal function, electrocardiogram and echocardiography were observed. RESULTS: After 12 weeks¬ð treatment, left atrium (LA) diameter, left ventricular end diastolic diameter(LVDD), left ventricular end systolic diameter(LVSD) and left ventricular ejection fraction (EF) were improved significantly in both groups (P<0.01). LVDD, LVSD EF and NYHA class were more significant in group A than those in group B (P<0.05). There was a significant difference of adverse reaction before and after the treatment between the 2 groups (P<0.05). CONCLUSION: Irbesartan combined with captopril is more effective than captopril alone in the treatment of patients with CHF. ......