外周血单核细胞_____外周血单核细胞；NFκB；支架

经皮冠状动脉内支架植入术对外周血单核细胞NFκB活性的影响

http://www.100md.com 《第四军医大学学报》 2005年第16期

外周血单核细胞,,外周血单核细胞；NFκB；支架,0引言,1对象和方法,2结果,3讨论,【参考文献】

     Activation of NFκB induced by coronary stent placement in peripheral blood mononuclear cells

    WANG Hui, YANG ZhiJian, HUANG Jun, ZHU TieBing, WANG LianSheng, CAO KeJiang

    Department of cardiology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China

    【Abstract】 AIM: To investigate the effect of coronary stenting on the activation of NFκB in peripheral blood mononuclear cells (PBMC). METHODS: Fifty patients were classified into two groups: 28 patients in stenttreatment group and 22 in coronary angiography (CAG). The levels of NFκB activity preprocedural and during the days after stent placement were determined using electrophoresis mobility shift assay (EMSA). RESULTS: The levels of NFκB activity in stenttreatment group from preprocedural to the 4th hour, 1st, 2nd and 3rd days after stent placement were (1.17±0.25) fold, (1.23±0.30) fold, (2.00±0.45) (2.49±0.46) fold and (2.25±0.4) fold respectively. Significantly increased levels of NFκB activity were seen in the 1st, 2nd and 3rd days (P<0.05). No alteration of NFκB activity was seen in CAG group. CONCLUSION: Increased level of NFκB activation in PBMC may be involved in the stent injury of the targeted vessel wall. ......

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