热休克蛋白质70__(期刊论文)

短期学习记忆对小鼠脑组织内热休克蛋白表达的影响

http://www.100md.com 《第四军医大学学报》 2005年第24期

热休克蛋白质70,,学习；记忆；Morris水迷宫；热休克蛋白质70；热休克蛋白质27；免疫组织化学,0引言,1材料和方法,2结果,3讨论,【参考

     Expression of HSP in the mouse brain after shortterm learning and memory

    YANG Fen, WAN Qi

    Department of Neurology, Xijing Hospital, Fourth Military Medical University, Xian 710033, China

    【Abstract】 AIM: To investigate the association of heat shock proteins (HSP70 and HSP27) with shortterm learning and memory. METHODS: Thirty mice were randomly divided into 3 groups: Trained group(TG), swimming control group (SC) and blank control group(BC). After shortterm training, the mice were killed and the brains were prepared for tissue section. An immunohistochemical method was used in detecting HSP70 and HSP27 expression. RESULTS: A significant increase in HSP70 levels was observed in hippocampus, cerebral cortex and nucleus amygdala in shortterm trained group, a little expression in SC group and hardly no expression in BC group. But no HSP27 expression was found in all the 3 groups. CONCLUSION: HSP70 may be a critical molecule involved in shortterm learning and memory.

    【Keywords】 learning; memory; Morris water maze; heatshock proteins 70; heatshock proteins 27; immunohistochemistry ......

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