【摘要】 目的 了解锌干预后孕妇不同孕期全血中微量元素含量的变化规律，探讨锌干预对新生儿生长发育的影响。 方法 在广西医科大学一附院定期孕检的孕妇中，选择孕龄小于12w、自愿接受锌补充且健康的335名孕妇作为干预对象;每名干预对象按对照条件选取1名健康孕妇作为对照。分别在第一次孕期保健、孕27～29w及产前抽取孕妇静脉血，用原子吸收分光光度法检测所有研究对象全血Zn、Fe、Cu、Ca、Mg的浓度。同时，对孕妇进行问卷调查。 结果 孕早期对照组和干预组全血Zn浓度差异无统计学意义，而孕中期和孕晚期两组全血Zn浓度差异有统计学意义，且干预组比对照组的高。对照组与干预组孕妇不同孕期的Fe、Ca、Mg元素的浓度差异均有统计学意义，并随孕期进展逐渐下降，而Cu浓度逐渐上升。干预组新生儿的出生体重、头围、身长及1分钟Apgar评分均大于对照组(P<0.01)。 结论 对孕妇每日补充适量的锌制剂可改善孕中、晚期的锌营养状态，提高新生儿的生长发育指标。

    【关键词】 孕龄;元素，锌;生长和胚胎发育

    Effects of zinc intervention on whole blood trace element concentration in pregnant women and new-born development

    ZENG Xiao-yun ，QIU Xiao-qiang，HUANG Dong，LI Mu-yan.

    1.Depart-ment of Epidemiology and Health Statistics，School of Public Health，Guangxi Medical University，Nanning 530021，China;2.Experiment Center for Medical Sciences，GuangXi Medical Universi-ty，Nanning 530021，China

    【Abstract】 Objective To observe the changes of whole blood trace element concentration in pregnant women，and to explore the effect of newborn development after zinc intervention.Methods The sub-jects were selected from pregnant women who took regular pregnant examination in the First Affiliated Hospital of Guangxi Medical University(FAHGMU).335volunteer pregnant women were selected as subjects.Whole blood samples were collected at their first pregnant examination ......