周围神经损伤_____神经生物学；肌源神经营养因子；

肌源神经营养因子修复大鼠周围神经损伤

http://www.100md.com 《第四军医大学学报》 2006年第1期

周围神经损伤,,神经生物学；肌源神经营养因子；,周围神经损伤；,周围神经再生；,辣根过氧化物酶；大鼠,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Musclederived neurotrophic factor used in repairing peripheral nerve injury in rats

    ZHANG LianBin, LIU Ying，CHU XiangYang，E LingLing，WANG Bo

    Department of Thoracic Surgery, PLA General Hospital, Beijing 100853, China

    【Abstract】 AIM: To observe the effect of musclederived neurotrophic factor (MDNF) in repairing peripheral nerve injury in rats. METHODS: MDNF was extracted from adult rat skeletal muscle, and 10 μL MDNF (0.1 mg/L) and 10 μL sodium solution were respectively injected into the injured sciatic nerve segments. Sodium solution group and normal rats were employed as controls. The morphologic observation and stereological measurement of regenerated nerve were evaluated by HRP retrograde tracing method and Nissls staining and trichrome staining techniques. RESULTS: Some regenerated fibers passed through the injected sciatic nerve segments in MDNF group. The morphologic observation and stereological measurement of nerve regeneration by MDNF injection were better than those in sodium solution group. CONCLUSION: MDNF can promote the regeneration of injured peripheral nerves. ......

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