骨髓移植_____嵌合体模型；全身照射；骨髓移植

持久稳定的大鼠→小鼠造血嵌合体模型的建立

http://www.100md.com 《第四军医大学学报》 2005年第24期

骨髓移植,,嵌合体模型；全身照射；骨髓移植,0引言,1材料和方法,2结果,3讨论,【参考文献】

     Establishment of stable rat→mouse hematopoietic chimera model

    WU XiaoJuan, LI ChunFu, TANG XiangFeng, SHI Lei

    1Department of Pediatrics, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China, 2Department of Pediatrics, Navy General Hospital, Beijing 100043, China

    【Abstract】 AIM: To establish a stable animal model of hematopoietic chimerism. METHODS: Conditioned SD rats received bone marrow cells from BALB/c mouse to induce xenogeneic chimeric rats. Thirty days later, lethally irradiated BALB/c mice received bone marrow cells from chimeric rats and their survival rate was monitored daily. Recipients splenic cells were stimulated in mixed lymphocyte culture (MLC) with xenoantigen and skin transplantation was carried out on day 30. RESULTS: Acute graft versus host disease was significantly alleviated, the survival time was prolonged and T cell proliferation was inhibited. More stable xenogeneic chimerism over 90 d was achieved via reverse bone marrow transplantation. CONCLUSION: A longterm xenogeneic chimera model is established by transplanting bone marrow cells of chimeras. ......

百拇医药网 http://www.100md.com/html/DirDu/2006/03/12/94/87/90.htm

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