Relation between preoperative chemotherapy and expression of p27 and Ki67 in tissues of esophageal carcinoma

    ZHU Kun, DANG ChengXue, LI Kang

    Department of Oncology Surgery, First Hospital, Xian Jiaotong University, Xian 710061, China

    【Abstract】 AIM: To study the relation between preoperative chemotherapy and expression of p27 and Ki67 in tissues of esophageal carcinoma. METHODS: A total of 48 patients with esophageal carcinoma were assigned to 2 groups: a control group (n=24) that received esophagectomy without chemotherapy and a preoperative chemotherapy group that received preoperative chemotherapy before esophagectomy (n=24). All the patients were followed up for 40 months. Immunohistochemical staining was used to determine the expression of p27 and Ki67 in the 48 cases. RESULTS: We found that the expression of p27 in esophageal tumor was associated with the histology grade of tumor (χ2=4.021, P=0.045), but not with carcinoma invasion degree (χ2=0.062, P=0.961), lymph node metastasis (χ2=0.006, P=0.936) and neoadjuvant chemotherapy (χ2=0.035, P=0.551). The expression of Ki67 was associated with the invasion degree (χ2=4.48, P=0.034) and lymph node metastasis (χ2=4.002, P=0.045) and neoadjuvant chemotherapy (χ2=5.371, P=0.02), but not with differentiation (χ2=0.488, P=0.4851). The median survival time was prolonged to 17 months in those who received neoadjuvant chemotherapy, but compared with the 14 months for those not receiving neoadjuvant chemotherapy there was no statistical significance (P>0.05). CONCLUSION: The expression of p27 and Ki67 can be used as important markers in assessing the prognosis and preoperative chemotherapy effect in patients with esophageal carcinoma. ...... 濡傛灉鎮ㄥ湪浣跨敤鎵嬫満绛夋祦瑙堟椂鏃犳硶鏌ョ湅鎴栦笅杞藉叏鏂囷紝鍙兘鏄鎼滅储寮曟搸澶辩湡鈥滆浆鐮佲€濓紝璇风偣鍑诲睆骞曟渶涓嬫柟鐨勨€滅數鑴戠増鈥濇垨鈥滃師缃戦〉鈥濊闂€�


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瀵邦喕淇婇弬鍥╃彿  閸忚櫕鏁為惂鐐  鐠囧嫯顔戦崙鐘插綖  閹兼粎鍌ㄩ弴鏉戭樋