Clinic significance of serum ILª²1, ILª²6, ILª²8 in patients with acute traumatic brain injury

    SUN Qunª²Zhou, DING Yongª²Zhong, ZHANG Jianª²Sheng

    Department of Neurosurgery, Second Hospital, Lanzhou University, Lanzhou 730030, China

    ¡¾Abstract¡¿ AIM: To explore the effect of serum ILª²1, ILª²6 and ILª²8 on the prognosis of patients with acute traumatic brain injury. METHODS: Fifty patients with acute traumatic brain injury were divided into 3 groups: mild injury group, moderate injury group and severe injury group. Samples were collected from peripheral venous blood respectively in patients on d1, d3 and d7 after injury and in 15 voluntary healthy people as controls. Serum ILª²1, ILª²6 and ILª²8 levels were measured by radioimmunoassay. RESULTS: Serum ILª²1, ILª²6 and ILª²8 levels in patients with severe traumatic brain injury were significantly higher than those in mild and moderate injury groups (P<0.01) on d1, d3 and d7. Serum ILª²6 and ILª²8 began to elevate on d1 and increased markedly on d3 and d7 with an increasing trend. ILª²1 peaked on d3 and dropped on d7 but it was still significantly higher than that in healthy group. CONCLUSION: Serum ILª²1, ILª²6 and ILª²8 levels elevate significantly in patients with severe brain trauma and they are associated with the injury degree and the prognosis of patients with acute traumatic brain injury. ......