Effect of lowª²dosage aspirin on vascular endothelial function of angina patients

    ZHAI Guiª²Lan,ZHU Huanª²Lin,QU Baoª²Ze,CAI Jiuª²Ying

    1Department of Cardiology, First Hospitol, Jinzhou Medical College, 2PLA 205 Hospital, Jinzhou 121001, China

    ¡¾Abstract¡¿ AIM: To investigate the effect of lowª²dosage aspirin on vascular endothelial function and serum ferritin (SF) of angina patients. METHODS: Sixty angina patients were paired according to the order of hospital admission and the types of angina and randomly divided into 2 groups: routine treatment group (nitrate ¦Âª²receptor blocker, Clopidogrel Hydrogen) and aspirin group (routine treatment and aspirin tablets 100 mg/d). Serum endothelinª²1 (ETª²1), nitric oxide (NO), flowª²mediated vasodilation (FMD) and SF were determined before and after treatment of 4 weeks. Thirty healthy subjects were chosen as the normal control group. Statistic analysis was performed in each group and between groups. RESULTS: ¢Ù Compared with normal controls, ETª²1 of angina patients increased significantly (P<0.05), and NO, FMD and SF decreased significantly (P<0.05). ¢Ú Compared with those before treatment, NO, FMD and SF of aspirin group increased significantly after treatment (P<0.05) and ETª²1 decreased significantly (P<0.05). ¢Û Compared with those in routine treatment group, NO, FMD and SF of aspirin group increased significantly after treatment (P<0.05) and ETª²1 decreased significantly (P<0.05). CONCLUSION: Lowª²dosage aspirin can distinctly improve vascular endothelial function of angina patients, which is related to the increase of SF. ......