Clinical significance and assay of peripheral blood somatostatin, TNFª²¦Á, ILª²6, sILª²2R in patients with gastrointestinal cancer

    LU Feng£¬QIAO Ling£¬WAN Juª²Ping

    1Cellular and Molecular Immunology Laboratory, Medical School of Henan University, 2Department of Internal Medicine, Huaihe Hospital, Henan University, Kaifeng 475001, China

    ¡¾Abstract¡¿ AIM: To observe the changes of peripheral blood somatostatin (SS), tumor necrosis factorª²¦Á (TNFª²¦Á), interleukinª²6 (ILª²6) and soluble interleukinª²2 receptor (sILª²2R) levels in patients with gastrointestinal cancer. METHODS: The subjects were divided into 4 groups: 23 cases in normal control group, 37 patients in gastric cancer group, 23 patients in colon carcinoma group and 29 patients in rectal cancer group. The levels of TNFª²¦Á, ILª²6 and sILª²2R were assayed with ELISA and SS was assayed with RIA. RESULTS: Compared with that in control group, the level of SS decreased significantly in gastric cancer group, colon cancer group and rectal cancer group, but the serum levels of ILª²6 and sILª²2R increased remarkably. The levels of ILª²6 and sILª²2R were significantly different in the 3 types of gastrointestinal cancer (P<0.05). Significant difference was found in the level of TNFª²¦Á when control group and gastric cancer group were compared with colon and rectal cancer groups (P<0.05). CONCLUSION: The detection of the changes of peripheral blood SS, TNFª²¦Á, ILª²6 and sILª²2R is of some clinical significance in the diagnosis and differentiation of patients with gastrointestinal cancer. ......