Application of simulated annealing and UV spectroscopy in multicomponent analysis of Vit.B

    QIU Xiª²Min, CHEN Wen, LI Liª²Li, ZHANG Ping, LIU Shengª²Zi, LING Xiao

    1Department of Analytical Chemistry Faculty of Pharmacy, Medical College, Hunan Normal University, Changsha 410006, China, 2Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha 410001, China

    ¡¾Abstract¡¿ AIM: To work out simulated annealing algorithm which bypasses partial but reaches whole optimization and which is combined with ultraª²violet (UV) and infrared radiation (IR) spectroscopy method to resolve overlapped peaks and to analyze multiple components. METHODS: Simulated annealing algorithm combined with UV spectroscopy was used to simultaneously determine the four contents in compound pharmaceuticalsª²VB. RESULTS: The recoveries of Vit.B1, B2, B6 and NA were 100.1%, 100.2%, 99.9% and 100.1% respectively. CONCLUSION: The simulated annealing algorithm combined with UV is suitable for the simultaneous determination of multiª²components in compound pharmaceuticals.

    ¡¾Keywords¡¿ simulate anneal arithmetic; multivariate analysis; spectrum analysis; compound pharmaª²ceutical products; thiamine; riboflavin; vitamin B6; niacinamide ......