Study on neuronª²protective effect of different doses of naloxone in patients with intracerebral hemorrhage

    LIU Daª²Jian, LIU Shen

    Department of Neurology, Huaihe Hospital, Henan University, Kaifeng 475000, China

    ¡¾Abstract¡¿ AIM: To explore the doseª²effect relationship of neuronª²protective effect of different doses of naloxone in patients with intracerebral hemorrhage. METHODS: One hundred and twenty patients were randomly divided into 3 groups of 40 cases each: high dose (H), medium dose (M) and low dose (L) groups. The hematoma volume and edemaª²zone areas, the level of neuron specific enolase (NSE) in serum, nerveª²functionª²defect score and the ADL score were examined at particular time respectively. RESULTS: ¢Ù There were significant differences in the hematoma volume and edemaª²zone area at different times points within a group (P<0.001). However, among different groups, the hematoma volume of L group was larger than those of H and M groups at 10 d (P<0.001) and the edemaª²zone area of L group was larger than that of M and H groups(P<0.002). But at 20 d, there was no significant difference in the hematoma volume and edemaª²zone area among the 3 groups. ¢Ú There was an increase of NSE in serum at 12 h after hemorrhage in all the patients. Moreover, NSE significantly decreased at 20 d and there were significant differences among the groups. The level of NSE in H group was lower than that in M group and that in M group was lower than that in L group(P<0.001). ¢Û The nerveª²functionª²defect scores of H group was higher than those of M group and L group at 20 d(P<0.02). The ADL scores of H group was higher than that of M group and the score of M group was higher than that of L group at 3 mo(P<0.001). CONCLUSION: Therapy with naloxone of 0.3 mg/(kg¡¤d) each day can protect neurons, decrease the function defect and improve living conditions in patients with intracerebral hemorrhage. ......