Ghrelin在大鼠神经系统中的表达对胃黏膜的保护作用
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徐 珞, 孙向荣, 韩晓华, 钟 凤, Inge
Ghrelin;胆碱乙酰转移酶;一氧化氮合酶;应激性胃溃疡;大鼠徐珞,孙向荣,韩晓华,钟凤,IngeDepoortered,TheoPeeters.Ghrelin在大鼠神经系统中的表达对胃黏膜的保护作
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徐珞, 孙向荣, 韩晓华, 钟凤, 青岛大学医学院 山东省青岛市 266021
Inge Depoortere, Theo Peeters, 天主教鲁汶大学 比利时 B-3000
徐珞, 女, 1954-10-26生, 青岛市人, 汉族, 2003年比利时天主教鲁汶大学博士毕业, 教授, 主要从事脑-肠肽结构和功能研究.国家自然科学基金资助项目, No.30470642
青岛市科技局资助项目, No.05-1-JC-93
通讯作者: 徐珞, 266021, 山东省青岛市登州路38号, 青岛大学医学院病理生理教研室. luoxukai@yahoo.com
电话: 0532-83056510 传真: 0532-83813986
收稿日期: 2006-01-03 接受日期: 2006-01-25
Expression of Ghrelin in nervous system and its cytoprotective action in rats
Luo Xu, Xian-Rong Sun, Xiao-Hua Han, Feng Zhong, Inge Depoortere, Theo Peeters
Luo Xu, Xiang-Rong Sun, Xiao-Hua Han, Feng Zhong, Department of Pathophysiology, Medical College of Qingdao University, Qingdao 266021, Shandong Province, China
Inge Depoortere, Theo Peeters, Department of Pathophysiology, Centre for Gastroenterological Research, Catholic University of Leuven, B-3000 Leuven, Belgium
Supported by National Natural Science Foundation of China, No.30470642, and the Fund from Qingdao Scientific and Technique Bureau, No. 05-1-JC-93
Correspondence to: Dr. Luo Xu, Department of Pathophysiology, Medical College of Qingdao University, 38 Dengzhou Road, Qingdao 266021, Shandong Province, China. luoxukai@yahoo.com
Received: 2006-01-03 Accepted: 2006-01-25
Abstract
AIM: To investigate the expression of Ghrelin in brain, intestinal myenteric plexus and plasma and study its possible cytoprotective effect and mechanism on gastric mucosa against stress-induced ulcers.
METHODS: Seventy-six healthy male Wistar rats were divided into 6 groups randomly: cold-water restraint group (n = 10); intracerebroventricular (icv) injection of Ghrelin group (n = 24); icv injection of Ghrelin after subcutaneous injection of Nω-Nitro-L-arginine methylester (L-NAME) group (n = 8) and three matched control groups. The expression of Ghrelin in rat brain, intestinal myenteric plexus and plasma were detected by radio-immunoassay (RIA) and double staining of immunofluorescence and immunohistochemistry ......
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