胃癌组织 Axin 蛋白的表达与侵袭转移的相关性
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郑亚民, 李 非, 董承伟, 伍晓汀
Axin蛋白;胃癌;肿瘤发生;肿瘤转移郑亚民,李非,董承伟,伍晓汀.胃癌组织Axin蛋白的表达与侵袭转移的相关性. 世界华人消化杂志2006;14(8)763-766,胃癌组织Axin蛋白
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郑亚民, 李非, 首都医科大学宣武医院普外科 北京市 100053
董承伟, 山东潍坊人民医院普外科 山东省潍坊市 261041
伍晓汀, 四川大学华西医院普外科 四川省成都市 610041
郑亚民，男，1971-10-03生, 河北省任丘市人, 汉族, 主治医师, 2005年四川大学华西临床医学院普外专业硕士, 现在读首都医科大学宣武医院普外专业博士.
通讯作者: 李非, 100053, 北京市宣武区长椿街45号, 首都医科大学宣武医院普外科. gsurger@tom.com
电话: 010-63013355-2705 传真：010-83154745
收稿日期: 2006-01-03 接受日期: 2006-01-25
Expression of Axin protein correlates with genesis and metastasis of gastric carcinoma
Ya-Min Zheng, Fei Li, Cheng-Wei Dong, Xiao-Ting Wu
Ya-Min Zheng, Fei Li, Department of General Surgery, Xuanwu Hospital, Capital University of Medical Sciences, Beijing 100053, China
Cheng-Wei Dong, Department of General Surgery, Weifang People’s Hospital, Weifang 261041, Shandong Province, China
Xiao-Ting Wu, Department of General Surgery, Huaxi Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Correspondence to: Dr. Fei Li, Department of General Surgery, Xuanwu Hospital, Capital University of Medical Sciences, 45 Changchun Street, Xuanwu District, Beijing 100053, China. gsurger@tom.com
Received: 2006-01-03 Accepted: 2006-01-25
Abstract
AIM: To investigate the relationship between Axin protein expression and genesis and metastasis of gastric carcinoma.
METHODS: A total of 46 patients with gastric carcinoma underwent surgical resection were included in this study. The expression of Axin protein was detected by immunohistochemical techniques (SABC) in paraffin-embedded samples prepared from gastric carcinoma tissues and normal stomach tissues far from the tumor. In addition, the positive rate of Axin expression was calculated and its corrrelation with the pathological characteristics of gastric carcinoma was analyzed.
RESULTS: In normal stomach tissues, Axin protein expression was strongly positive and intensified in basal cells. Axin was also expressed in tissues from gastric carcinoma and normal stomach mucosa far from the tumor with a positive rate of 62 ......
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