胶原酶门静脉灌注逆转兔CCl4性肝硬化
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金 博, 张志成, 孙 涛, 程留芳
肝硬化;胶原酶;门静脉;兔金博,张志成,孙涛,程留芳.胶原酶门静脉灌注逆转兔CCl4性肝硬化. 世界华人消化杂志2006;14(8)772-777,胶原酶门静脉灌注逆转兔CCl4性肝硬化
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金博, 张志成, 孙涛, 海军总医院消化内科 北京市 100037
程留芳, 解放军总医院消化内科 北京市 100853
金博, 2005年军医进修学院博士, 日本富山医科药科大学客座研究员, 美国国立卫生研究院博士后, 副主任医师, 主要从事肝脏病及消化道疾病的研究.
通讯作者: 金博, 100037, 北京市阜成路6号, 海军总医院消化内科. bjbo_jin@hotmail.com
电话: 010-87026435 传真: 010-68589301
收稿日期: 2006-01-04 接受日期: 2006-01-25
Portal collagenase administration reverses carbon tetrachloride-induced rabbit liver cirrhosis
Bo Jin, Zhi-Cheng Zhang, Tao Sun, Liu-Fang Cheng
Bo Jin, Zhi-Cheng Zhang, Tao Sun, Department of Digestive Diseases, Naval General Hospital, Beijing 100037, China
Liu-Fang Cheng, Department of Digestive Diseases, Chinese PLA General Hospital, Beijing 100853, China
Correspondence to: Dr. Bo Jin, Department of Digestive Diseases, Naval General Hospital, Beijing 100037,China. bjbo_jin@hotmail.com
Received: 2006-01-04 Accepted: 2006-01-25
Abstract
AIM: To investigate whether portal collagenase administration can reverse liver cirrhosis.
METHODS: Four normal controls (group A) received olive oil subcutaneously (sc) for 12 weeks followed by normal saline portal perfusion for 12 weeks. Another four rabbits (group B) received carbon tetrachloride (CCl4) sc for 12 weeks and then 6 mg of collagenase portally for 12 weeks, while three control rabbits (group C) received CCl4 for 12 weeks followed by saline for 12 weeks.
RESULTS:After 12 weeks of CCl4 and another 12 weeks of portal vein perfusion, liver hydroxyproline content in collagenase-treated rabbits was significantly decreased as compared with that in saline-treated controls (177.5 ± 35.6 mg/gvs 446.3 ± 150.1 mg/g;F = 13.78, P < 0.01). Further, liver histology showed complete regression of cirrhosis in the collagenase-treated animals. No toxicity of liver, kidney, lung, brain or heart was observed histologically. Anaphylaxis occurred in 2 animals and one was fatal ......
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