糖尿病早期肾病患者血清同型半胱氨酸的变化及临床意义
糖尿病,,同型半胱氨酸；2型糖尿病；糖尿病肾病；肌酐清除率；尿白蛋白排泄率,1临床资料,2结果,3讨论,参考文献
【摘要】 目的 探讨2型糖尿病早期肾病患者血清总同型半胱氨酸(tHCY)浓度的变化，并分析其影响因素和临床意义。方法 应用荧光偏振免疫发光法测定血清tHCY浓度。结果 ①2型糖尿病微量白蛋白尿组血清tHCY水平明显高于正常白蛋白尿组和正常对照组(P＝0013，P＝0024)，正常白蛋白尿组血清tHCY水平与正常对照组相比差异无显著性(P＝0644)；②经多元逐步回归分析，CCr、TG是糖尿病患者血清tHCY浓度的独立影响因素，血清tHCY浓度和DM病程是尿白蛋白排泄率(UAER)的独立影响因素。结论 ①2型糖尿病微量白蛋白尿患者血清tHCY浓度升高，CCr是血清tHCY浓度的独立影响因素；②高HCY血症与2型DM早期肾病的发生、发展有关。【关键词】 同型半胱氨酸；2型糖尿病；糖尿病肾病；肌酐清除率；尿白蛋白排泄率
Change of serum total homocysteine in type 2 diabetics with
incipient diabetic nephropathy and its clinical significance
MAO Yanhua ZONG Kecheng
1 Department of Internal Medicine，Binzhou Medical College,Binzhou 256603；2 People's Hospital of Huantai County
【Abstract】 Objective To investigate the change of serum total homocysteine in type 2 diabetics with incipient diabetic nephropathy and its clinical significance.Methods Serum tHCY levels were measured by fluorescence polarization immunoassay(FPIA) in 60 patients with type 2 diabetes and 30 healthy control subjects.The relationship between tHCY and FPG,HbA1c,FINS,Homa IR,SCr,CCr,TG,TC or UA was analysed.Results ①The serum tHCY level was higher in patients with type 2 diabetes mellitus with microalbuminuria than that in patients with normoalbuminuria and that in control subjects[(1162±426)μmol/L vs(973±241)μmol/L,P＝0013；(1162±426)μmol/L vs(934±264)μmol/L,P＝0024] ......
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