关键词: 不育，男(雄)性;Y染色体;染色体缺失;基因

    摘 要:目的 探讨Y染色体微缺失与原因不明性无精症、少精症所致男性不育的相关性. 方法 特发性少精症18例、特发性严重少精症12例、特发性无精症5例及正常已生育健康男性10例作为研究对象和正常对照.应用多重PCR技术，对精液基因组DNA进行Y染色体上连续的18个序列标记位点检测. 结果 少精症18例中发现Y染色体微缺失2例，严重少精症12例中发现Y染色体微缺失3例.无精症5例和正常已生育男性10例均末发现Y染色体微缺失.缺失形式3种. 结论 Y染色体微缺失与精子发生障碍相关.

    Relationship between Y chromosome microdeletion and male infertility

    LIU Fang CHEN Bi-Liang SU Ming-Quang WANG De-Tang

    1 Department of Obstetrics&Gynecology，

    2 Center of Molecular Biology，Xijing Hospital，Fourth Mili-tary Medical University，Xi'an710033，China

    Keywords:infertility，male;Y chromosome;chromosome deletion;genes

    Abstract:AIM To evaluate the microdeletion of Y chromo-some in infertile men with idiopathic azoospermia and oligo┐zoospermia.METHODS 18patients with idiopathic a-zoospermia ......