关键词: 氟伐他汀;放射性肺损伤;转化生长因子β

    摘 要:目的 探讨氟伐他汀(fluvastatin)对放射性肺损伤TGF-β1 表达的影响. 方法 将SD大鼠随机分为对照组、单纯照射组和氟伐他汀防治组，防治组于照射前1wk以氟伐他汀20mg·kg-1 灌胃，1次·d-1 ，直至实验结束.其他组灌服生理盐水.直线加速器全胸部照射，单次剂量为20Gy，照后5，15，30和60d剪开胸腔，取肺组织做病理切片，并作TGF-β1 免疫组化染色，光镜下观察染色结果. 结果 放疗组显示随着照射后时间延长，TGF-β1 在肺组织表达逐渐增强，氟伐他汀防治组显示TGF-β1 的表达不随病情发展而增强.与各时间点放射组相比明显减弱. 结论 氟伐他汀能明显减弱TGF-β1 表达，为防治放射性肺损伤提供了实验依据.

    Effect of fluvastatin on transforming growth factor beta1 in rats with radiation┐induced lung injury

    YE Jiang-Feng QI Hao-Wen FAN Feng-Yun ZHAO Feng WEI Wen-Sheng ZHAO Yi-Ling SHI Mei

    1 Department of Respiratory Diseases，

    2 Department of Radiation Therapy，Xijing Hospital，

    3 Department of Pathology，Faculty of Preclinical Medicine，Fourth Millitary Medical University，Xi'an710033，China

    Keywords:fluvastatin;radiation-induced lung injury;trans-forming growth factor beta

    Abstract:AIM To investigate the effects of fluvastatin on transforming growth factor beta1 (TGF-beta1 )in rats with ra-diation-induced lung injury.METHODS SD rats were divid-ed randomly into3groups:normal control ......