重症急性胰腺炎肺损伤内皮素的变化及丹参的治疗作用
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黄晓丽, 刘顺英, 王国品, 曾皓明, 杨 丽,
胰腺炎;肺损伤;内皮素;丹参,黄晓丽,刘顺英,王国品,曾皓明,杨丽,王智,Changesofendothelinlevelsandtherap
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黄晓丽, 东南大学临床医学院, 东南大学附属南京江北人民医院消化科 江苏省南京市 210048
刘顺英, 东南大学附属中大医院消化科 江苏省南京市 210009
王国品, 曾皓明, 杨丽, 东南大学附属南京江北人民医院 江苏省南京市 210048
王智, 东南大学临床医学院 江苏省南京市 210009
黄晓丽, 2006年东南大学医学院硕士生, 从事重症胰腺炎诊断和治疗研究.
南京市科技发展项目, No. YKK0465
通讯作者: 刘顺英, 210009, 江苏省南京市丁家桥87号, 东南大学附属中大医院消化科.
电话: 025-83272034
收稿日期: 2005-12-22 接受日期: 2006-02-21
Changes of endothelin levels and therapeutic effects of Danshen in lung injury induced by severe acute pancreatitis in rats
Xiao-Li Huang, Shun-Ying Liu, Guo-Pin Wang, Hao-Ming Zeng, Li Yang, Zhi Wang
Xiao-Li Huang, Clinical Medical College of Southeast University; Department of Gastroenterology, Nanjing Jiangbei Municipal People’s Hospital, Nanjing 210048, Jiangsu Province, China
Shun-Ying Liu, Department of Gastroenterology, the Affiliated Zhongda Hospital of Southeast University, Nanjing 210009, Jiangsu Province, China
Guo-Pin Wang, Hao-Ming Zeng, Li Yang, Nanjing Jiangbei Municipal People’s Hospital, Nanjing 210048, Jiangsu Province, China
Zhi Wang, Clinical Medical College of Southeast University, Nanjing 210009, Jiangsu Province, China
Supported by Nanjing Science and Technology Development Program, No. YKK0465
Correspondence to: Department of Gastroenterology, the Affiliated Zhongda Hospital of Southeast University, Nanjing 210009, Jiangsu Province, China
Received: 2005-12-22 Accepted: 2006-02-21
Abstract
AIM: To explore the changes of endothelin (ET) levels, in serum and lung, and the therapeutic effects of labiatae on severe acute pancreatitis (SAP) with lung injury in rats.
METHODS: A total of 60 Wistar rats were randomized into sham operation group (J), model group (F), and Danshen treatment group (D). The model of SAP was established by retrograde injection of 50 g/L sodium taurocholate into the pancreatic and biliary duct ......
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