茶多酚对雷公藤内酯醇致小鼠肝损害的保护作用
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李钦民, 韩 真
雷公藤内酯醇;茶多酚;肝毒性;脂质过氧化,李钦民,韩真,Protectiveeffectsofteapolyphenolsonliveragainsttr
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李钦民, 韩真, 皖南医学院附属弋矶山医院消化内科 安徽省芜湖市 241001
通讯作者: 韩真, 241001, 安徽省芜湖市, 皖南医学院附属弋矶山医院消化内科. liqm1029@sohu.com
电话: 0553-5738856-2316 传真：0553-573999-2021
收稿日期: 2006-01-20 接受日期: 2006-02-09
Protective effects of tea polyphenols on liver against triptolide-induced hepatic injury in mice
Qin-Min Li, Zhen Han
Qin-Min Li, Zhen Han, Department of Gastroenterology, Yijishan Hospital, Wannan Medical College, Wuhu 241001, Anhui Province, China
Correspondence to: Zhen Han, Department of Gastroenterology, Yijishan Hospital, Wannan Medical College, Wuhu 241001, Anhui Province, China. liqm1029@sohu.com
Received: 2006-01-20 Accepted: 2006-02-09
Abstract
AIM: To investigate the effects of tea poly-phenols (TP) on liver toxicity induced by triptolide (TPI) in mice, and to explore the correlated mechanism.
METHODS: Seventy mice were randomly and averagely divided into five groups: high dose TPI (0.03 mg/kg) group, low dose TPI (0.015 mg/kg) group, high dose TPI (0.03 mg/kg) plus TP (300 mg/kg) group, low dose TPI (0.03 mg/kg) plus TP(300 mg/kg) group, and control group. After treatment with the corresponding methods for 60 d, we observed the levels of serum alanine aminotransferase (ALT), alkaline phosphatase (ALP), the activities of superoxide dismutase (SOD), glutathione S-transferase (GST), and the contents of malondialdehyde (MDA) in liver homogenate, as well as the histopathological changes of liver and kidney.
RESULTS: In comparison with those in control group, the level of serum ALT and the content of hepatic MDA were significantly elevated in group A and B (ALT: 63.7 ± 10.9, 95.8 ± 12.5 μkat/L vs 38.2 ± 5.6 μkat/L, P < 0.01; MDA: 8.11 ± 1.38, 12.86 ± 2.01 nmol/mgp vs 6.39 ± 0.98 nmol/mgp, P < 0.05 or P < 0.01), while the activities of hepatic SOD and GST were significantly dropped (92.31 ± 10.26, 75.93 ± 9.11 U/mgp vs 122 ......
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