免疫(疫苗)微球稳定性的研究进展
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刘淑平，王东凯，张 蓓
(沈阳药科大学 药学院, 辽宁 沈阳 110016)
摘 要：免疫(疫苗)微球可以通过提高抗原的浓度、加入多种抗原或非抗原蛋白质、加入表面活性剂和等渗剂等方法来提高在微囊化过程中抗原的稳定性；形成不溶性金属复合物、使用 pH 调节剂和添加剂以及进行化学修饰等可以保持抗原在体外释放试验中的稳定性；另外，采用更适宜的制备微球的技术和适当的聚合物也可提高抗原的稳定性，对提高免疫(疫苗)微球稳定性的的方法进行综述。
关键词: 药剂学；微球；综述；抗原；稳定性；生物可降解聚合物
中图分类号：R944 文献标识码 ：A
The progress of study on the stability of vaccine microspheres
LIU Shu-ping, WANG Dong-kai, ZHANG Bei
(School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016，China)
Abstract: The progress of study on the stability of vaccine microspheres was reviewed and the factors affecting the stability of antigen were introduced. The stability of antigen during microencapsulation could be improved by the increase of antigen concentration, addition of several other antigens, nonantigenic proteins, surfactants or isotonizing agent. And its stability in vitro release test could be maintained through formation of insoluble metal complexes, addition of pH modifiers and additives or chemical modification.
Key words：pharmaceutics；microspheres；review；antigen；stability；biodegradable polymers
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