【摘要】 目的 探讨小剂量西比灵治疗偏头痛的临床疗效。方法 将常规剂量西比灵治疗偏头痛效果不佳病人改为半量(2.5mg/d)治疗，并与常规剂量相比较。对所有治疗病人进行头痛发作期症状控制率及发作频率的效果、总有效率和远期疗效进行观察比较。结果 小剂量西比灵组和常规用量组对比，小剂量治疗组对其头痛发作控制率(25%)和总有效率(81%)均较后组有较好效果，两组差异有非常显著性(P<0.001)。结论 对服用常规剂量西比灵后无效甚至症状加重的偏头痛患者，小剂量西比灵仍有较好治疗效果，显效率高，且远期治疗效果好。

    【关键词】 小剂量；西比灵；偏头痛

    Clinical study of low dose flunarizine treating the patients with migraine

    YANG Sen,WANG Hu,WANG Qi,et al.

    The Second Affiliated Hospital of Xuzhou Medical College, Xuzhou 221006,China

    【Abstract】 Objective To study the clinical effect of low doze flunarizine on the patients with migraine.Methods In study group:The patients took the flunarizine half of the conventional dose who had no satisfied effect with conventional dose(2.5mg/d).In control group:The patients took conventional dose(5mg/d).Compared the control rate and the outbreak frequency in the course of headache,the total effect rate and the long-term effect in the two groups.Results The study group had better effect than the control group in the control rate and the total effect rate. There were statistical difference between the two groups(P<0.01).Conclusion Low dose flunarizine has good effect to the patients with migraine while the conventional dose is invalid or even worse.The total effect rate and the long-term effect in the study group are encouraging. ......