辅酶Q10脂质体的制备及稳定性研究

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     李 喆，邓英杰，李保齐，杨静文，张修宇，雷国峰

    (沈阳药科大学 药学院，辽宁 沈阳 110016)

    摘要：目的 制备辅酶Q₁₀脂质体，并考察其稳定性。方法 采用乙醇注入法制备辅酶Q₁₀脂质体，并考察其稳定性。结果 制备的辅酶Q₁₀脂质体在25 ℃和40 ℃下较稳定，在60 ℃下较不稳定，在光照条件下很不稳定。结论 辅酶Q₁₀脂质体制备工艺简单，包封率高，粒径小而均一，稳定性较好。

    关键词：药剂学；脂质体；乙醇注入；辅酶Q₁₀；稳定性

    Studies on the preparation and stability of CoQ₁₀ liposome

    LI Zhe, DENG Ying-jie, LI Bao-qi, YANG Jing-wen, ZHANG Xiu-yu, LEI Guo-feng

    (School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China)

    Abstract: Objective To prepare Coenzyme Q10 (CoQ₁₀) liposome, and study its stability. Method The CoQ₁₀ liposome was prepared by ethanol injection method, and stability of CoQ₁₀ liposome was reviewed. Results The CoQ₁₀ liposome was stable at 25 ℃ and 40 ℃,and unstable at 60℃. Conclusion The CoQ₁₀ liposome prepared by ethanol injection is stable , with a high encapsulation efficiency, small particle sizes and narrow distribution.

    Key word: pharmaceutics; liposomes; ethanol injection; coenzyme Q₁₀; stability

    http://www.100md.com/html/DirDu/2006/03/29/95/95/87.htm

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