【摘要】 目的 探讨非霍奇金淋巴瘤骨髓侵犯患者的临床特征、病理分类、治疗及转归情况。方法 17例患者行淋巴结活检、血常规、骨髓检查，分析其骨髓侵犯发生率、病理组织类型、临床分期等，并采取相应的治疗方案。结果 骨髓侵犯发生率19%，年龄35岁以下、病理类型T细胞型、临床分期晚期居多，化疗治疗其缓解期较短，自体移植复发率高，异基因骨髓移植无病生存时间长。结论 异基因骨髓移植是治疗本病的最佳选择。

    【关键词】 淋巴瘤；骨髓侵犯；临床观察

    Studies on bone marrow involvement of non-Hodgkins lymphoma in 17 cases

    XUE Mei，WANG Heng-xiang，ZHU Ling，et al.

    Air Force General Hospital,Beijing 100036,China

    【Abstract】 Objective To investigate the clinical features,pathomorphological features,therapy regime and clinical course of bone marrow involvement of non-Hodgkins lymphoma.Methods To analyse the incidence of bone marrow involvement in patient with NHL,the histological characteristics of individual lymphomas and the clinical stage,to choose the rational regime for treatment.Results bone marrow involvement of non-Hodgkins lymphoma(NHLBMI) occurred in 17 of 89 (19%) cases.There were 16 patients with T cell-lymphoma and 11 patients with 3 and 4 stage and 10 patients was under 35 years old.The remission interval was short in patients treated by chamotherapy.The relapse rate was high in patients by autologous transplantation.Long-term disease-free survival was achieved in patients treated by allo-genetic transplantation.Conclusion The NHLBMI is related to clinical manifestations.The best way to cure this disease was allo-genetic transplantation. ......