直肠癌C-erbB-2、nm23蛋白表达的相关性与预后的关系
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高凤兰
直肠癌;nm23;C-erbB-2;相关性;预后高凤兰.直肠癌C-erbB-2、nm23蛋白表达与预后的关系. 世界华人消化杂志2006;14(10)1015-1018 直肠癌
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高凤兰, 漯河医学高等专科学校病理教研室, 病理研究中心462000
通讯作者: 高凤兰, 462000, 漯河医学高等专科学校, 漯河市大学路148号. lhyzgao@126.com
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收稿日期: 2006-02-13 接受日期: 2006-03-07
The relationship between the expression of C-erbB-2, nm23 protein in tissue of rectal cancer and its prognostication
Gao Fenglan
Gao Fenglan, Department of Pathematology, Medical school of Luohe, Luohe 462000, China
Correspondence to: Feng-Lan Gao, Department of Pathology, Luohe Medical School, 148 Daxue Road, Luohe 462000, Henan Province, China. lhyzgao@126.com
Received: 2006-02-13 Accepted: 2006-03-07
Abstract
AIM: To study the relationship between the expression of C-erbB-2, nm23 protein in tissue of rectal cancer and its infilitration or metastasi.
METHODS: The expression of C-erbB-2, nm23 protein in sample of rectal cancer was detected by immunohistochemistry and its relationship to other factors and its prognostication were analyzed respectively.
RESULTS: The total positive rate of nm23 in tissue of rectal cancer was 78.8%(67/85). According to data of Dukes, the high level was higher in A state (80.9%) than that in C state (42.3%) and D state (27.7%) (), and similar to B state (75.0%) (P>0.05). The total positive rate of C-erbB-2 was 80%(68/85) and high expression rate in these samples was 54.1%(46/85). It was inverse correlation to expression of nm23. The level of C-erbB-2 in D state was high (77.7%) than that in A state (28.5%) and B state (30.0%) (P<0.05), and had little difference in C state (76.9%) (P>0.05). High level of nm23 was more common expressed in tissue of well-differentiated adencarcinoma (80%) than that in poorly differentiated adencarcinoma (25.0%), areolar cancer (10.5%) (P<0.05), and was similar to moderately differentiated adencarcinoma (71.49%) (P>0.05). High level of C-erbB-2 was more common expressed in tissue of poorly differentiated adencarcinoma (81 ......
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