益生菌及肠内外营养对重症急性胰腺炎大鼠肠道黏附分子及免疫屏障的影响
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杨建军, 耿 翔, 高志光, 秦环龙
益生菌;肠内营养;MAdCAM-1;重症急性胰腺炎杨建军,耿翔,高志光,秦环龙.益生菌及肠内外营养对重症急性胰腺炎大鼠肠道黏附分子及免疫屏障的影响. 世界华人消化杂志2006;14(10)
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杨建军, 耿翔, 高志光, 秦环龙, 上海交通大学附属第六人民医院普外科 上海市 200233
杨建军, 医学硕士, 主要从事普通外科研究工作.
上海交通大学昂立基金资助项目, No. KJ200501
通讯作者: 秦环龙, 200233, 上海市, 上海交通大学附属第六人民医院普外科. hlqin@sjtu.edu.cn
电话: 021-64942226 传真：021-64368920
收稿日期: 2006-02-06 接受日期: 2006-03-03
Effects of probiotics and enteral and parenteral nutrition on intestinal mucosal addressin cell adhesion molecule-1 and immune barrier of rats with severe acute pancreatitis
Jian-Jun Yang, Xiang Geng, Zhi-Guang Gao, Huan-Long Qin
Jian-Jun Yang, Xiang Geng, Zhi-Guang Gao, Huan-Long Qin, Department of General Surgery, the Sixth People’s Hospital of Shanghai Jiaotong University, Shanghai 200233, China
Supported by Angli Fund of Shanghai Jiaotong University, No. KJ200501
Correspondence to: Huan-Long Qin, Department of General Surgery, the Sixth People’s Hospital of Shanghai Jiaotong University, Shanghai 200233,China. hlqin@sjtu.edu.cn
Received: 2006-02-06 Accepted: 2006-03-03
Abstract
AIM: To investigate the effects of probiotics and enteral and parenteral nutrition (EN and PN) on peyer’s patch, intestinal mucosal addressin cell adhesion molecule-1 (MAdCAM-1) and immune barrier of rats with severe acute pancreatitis (SAP).
METHODS: SAP model was established in 30 Sprague Dawley (SD) rats via biliary and pancreatic duct using sodium taurocholate and then were averagely divided into 3 groups: PN group, PN + EN group, and PN + EN + probiotics group. Twenty-four hours after modeling, the rats in each group were treated with the corresponding methods for 6 days. The nutrition support in the 3 groups was isonitrogenic and isocaloric. At the 7th day, all the rats were sacrificed ......
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